If Manchester City beats Arsenal on Sunday, it will have a clearer path to securing a record fourth consecutive English Premier League title.
However, if City loses, Arsenal could take a significant step toward becoming league champions for the first time in two decades.
A draw, on the other hand, could benefit Liverpool the most this weekend.
With only 10 rounds left to play, the match at Etihad Stadium marks the final encounter between any of the three title contenders.
Arsenal currently leads the league standings, with Liverpool following closely behind in second place based on goal difference. Manchester City trails by just one point.
Both City and Arsenal face risks and potential rewards in this match.
City has a strong track record at home against Arsenal, having won their last eight encounters at Etihad Stadium. The last time City lost at home to Arsenal was in 2015.
However, Arsenal has shown improvement this season, particularly after defeating City in a penalty shootout to win the Community Shield in August, followed by a 1-0 victory at Emirates Stadium in October.
City manager Pep Guardiola faces challenges in preparing for this match due to injuries to key defenders Kyle Walker and John Stones during the international break.