Brandon Aiyuk will not play in the 2025 NFL season after the San Francisco 49ers placed him on the reserve/left squad list. The announcement, reported by NFL Network’s Ian Rapoport and confirmed on the league’s transaction wire, officially ends Aiyuk’s season before it even began.
Aiyuk’s Injury And Contract Issues Raise Questions About Future With 49ers Team
The wide receiver has been on the physically unable to perform list all year due to a torn ACL suffered in 2024. This long recovery period not only keeps him off the field for 2025 but also casts doubt on his future with the team.

Tensions between Aiyuk and the 49ers extend beyond injuries. The team recently voided the guaranteed money in his 2026 contract, a move that could pave the way for a separation. This comes only a year and a half after both sides agreed to a four-year, $120 million extension ahead of the 2024 season.
Aiyuk’s Standout Seasons Highlight Talent Despite Ongoing Tension With The 49ers Organization
Aiyuk has had several standout seasons with the 49ers. His 2023 campaign was a career-best, recording 1,342 yards and seven touchdowns on 75 receptions, earning him second-team All-Pro honors. He also led the team in receptions and yards in 2022, proving himself a key offensive weapon since being drafted in the first round in 2020.
The relationship between Aiyuk and the 49ers has been rocky, with past holdouts, trade requests, and recent contract disputes. Unless there is reconciliation this offseason, his placement on the reserve/left squad list could mark the conclusion of his five-year tenure in San Francisco.







