The San Francisco 49ers opened their preseason against the Denver Broncos without several rookies in action. Head coach Kyle Shanahan explained that rookie cornerback Upton Stout was sidelined due to calf tightness, a precautionary move for the projected starting nickel corner. In his place, Chase Lucas stepped up and impressed Shanahan, who likened him to an “Energizer Bunny” for his relentless energy and activity during the game.
Injuries Test 49ers Depth Ahead of Crucial Joint Practices with the Raiders
First-round rookie Mykel Williams missed the game with a hyperextended knee, and Shanahan expects him to be out for about a week. Safety Richie Grant is on a similar recovery timeline. Rookie safety Marques Sigle also suffered a knee injury, which the team believes is likely just a bruise. Shanahan highlighted Sigle’s growth in recent practices despite an earlier setback in the offseason and praised his performance in the game.

While the 49ers still have enough healthy players for upcoming joint practices with the Las Vegas Raiders, depth is becoming a concern. Nineteen players sat out the Denver game due to injuries, excluding those on the PUP list or the seven healthy scratches. Shanahan emphasized the importance of having strong practices on Monday and Tuesday before facing the Raiders, hoping several players will be ready to return in time.
Key 49ers Starters Nearing Return as Injuries Challenge Offensive and Defensive Depth
Second-year players Renardo Green and Jacob Cowing could return to practice this week, depending on their recovery progress. Green, slated as a starter, is an important piece of the defense, while Cowing needs live reps to continue developing. Shanahan hopes both will be back before competing against another team to ensure they are game-ready.
Cowing’s return holds added significance due to injuries to top wide receivers Brandon Aiyuk and Jauan Jennings. Their absences, combined with other injury setbacks, have forced the 49ers to rely on backups and depth players during the preseason. Shanahan’s cautious approach underscores the team’s focus on balancing preparation with long-term health as they move closer to the regular season.